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Rotate the site of injection to avoid irritation or sterile abscess formation with repeat administration. Intramuscular Depot injection (fluphenazine decanoate or . PACKAGE LEAFLET: INFORMATION FOR THE USER. Modecate® 25mg/ml Injection fluphenazine decanoate. Is this leaflet hard to see or read? Phone . ADMINISTRATION). Fluphenazine decanoate is not indicated for the management of severely agitated psychotic patients or psychoneurotic.

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Patients may need to be informed of the possibility of additive central nervous system CNS effects, such as sedation, dizziness, and CNS impairment. The risk of developing tardive dyskinesia and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotics administered to the patient increase. Clinical monitoring for adverse effects is recommended during coadministration.

The plasma concentrations and the effects of fluphenazine may therefore be increased and prolonged by drugs that are either the substrates or inhibitors of this P isoform, possibly resulting in severe hypotension, cardiac arrhythmias or CNS side effects. Solution for Injection Pale yellow clear, oily liquid.

These reactions may be reduced by using smaller doses more frequently, or by the concomitant use of anti-parkinsonian drugs such as trihexyphenidyl, benzatropine or procyclidine. Additionally, rare cases of TdP have been spontaneously reported during postmarketing surveillance in patients receiving levofloxacin. Phenothiazines may impair body temperature regulation. According to the manufacturer, asenapine should be avoided in combination with other agents also known to have this effect e.

Fluphenazine is contraindicated in patients receiving large doses of hypnotics. Drugs with a possible risk for QT prolongation that should be used cautiously and with close monitoring with lapatinib include fluphenazine.

This list is not exhaustive. Hyperglycemia and glycosuria have been reported. According to the manufacturer, since iloperidone may prolong the QT interval, it should not be used with other agents also known to have this effect, such as fluphenazine. Fluphenazine should be used cautiously during dental work, surgery, and other procedures where the use of CNS depressant medications is common. Depending on the specific agent, additive anticholinergic effects may also be seen; clinicians should note that antimuscarinic effects may be seen not only on GI smooth muscle, but also on bladder function, the eye, and temperature regulation.


May increase gradually as needed and tolerated. Monitor patients for sedation or respiratory depression.

Modecate Injection 25mg/ml – Summary of Product Characteristics (SmPC) – (eMC)

Hydroxychloroquine increases the QT interval and should not be administered with other drugs known to prolong the QT interval. CNS effects, orthostatic hypotension, anticholinergic effects, and lowering of seizure threshold are potential problems with the combined use of amoxapine and antipsychotics.

Droperidol may also cause increased CNS sedation when given with flurphenazine. Available forms Available by prescription only fluphenazine decanoate Depot injection: Phenothiazines can also lower the seizure threshold, which may be important in patients taking a barbiturate for the treatment of seizures. Therefore, concurrent use fluphenaziine these drugs and fluphenazine is contraindicated.

Increases risk of seizures.

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Monitor patients during anagrelide therapy for cardiovascular effects and evaluate as necessary. Increased Mortality in Elderly ijsert with Dementia.

Phenothiazines should be discontinued 48 hours before the myelography and should not be resumed until at least 24 hours after the procedure. Likewise, the symptoms of certain medication toxicities i.

The causes of death were not available. Dilute fluphenazine just prior to administration with — mL of water, saline, milk, 7-Up, carbonated orange beverage, or the following juices: If these drugs are used together, consider electrocardiogram packgae.

Data regarding the safety of atypical antipsychotics during breast-feeding are limited, and chronic administration of any antipsychotic during breast-feeding should be avoided if possible. Additionally, elderly patients may be more susceptible to the actions and adverse effects of phenothiazines, including tardive dyskinesia, dystonias, orthostatic hypotension, and anticholinergic effects. Modecate contains benzyl alcohol as a preservative and must not be given to premature babies or neonates.

Marketing authorisation holder 8. Minor Due to a possible risk for QT prolongation and torsade de pointes TdPgranisetron and fluphenazine should be used together cautiously.

Hypothermia appears to occur more frequently during initiation of antipsychotic therapy or after dose increases. This site uses cookies. Severe Metoclopramide is a central dopamine antagonist and may cause extrapyramidal reactions e. Major Bupropion is associated with a dose-related risk of seizures. These effects have varied in severity from self-limited to requiring intensive care unit stays and prolonged hospitalization.


However, only the vasoconstrictors metaraminol or noradrenaline should be used, as adrenaline may further lower the blood pressure through interaction with the phenothiazine. Inject slowly and deeply into the upper outer quadrant of the gluteal muscle.

Initiate treatment with lower doses followed by careful dosage titration and close monitoring.

Modecate Injection 25mg/ml

The hypotensive effect of calcium channel blockers is enhanced by concurrent use of antipsychotic drugs. The National Pregnancy Registry for Psychiatric Medications is dedicated to evaluating the safety of psychiatric medications that may decanoat taken by women during pregnancy to treat a wide range of mood, anxiety, or indert disorders. Additive drowsiness or other CNS effects may also occur. In addition, fluphenazine is associated with a possible risk of QT prolongation; therefore, cardiac effects are possible.

In addition to these pharmacodynamic interactions, several individual anticonvulsant agents interact in multiple ways with phenothiazines. Minor Consider periodic monitoring of EGCs for QT prolongation and monitor electrolytes if coadministration of histrelin and fluphenazine is necessary; correct any electrolyte abnormalities. Foscarnet has been associated with postmarketing reports of both QT prolongation and torsade de pointes TdP.

Lofexidine may prolong the QT interval, and torsade de pointes TdP has been reported during postmarketing use. The impact of in utero exposure to antidepressants or antipsychotics compared to no psychotropic exposure was assessed in infants 6 months of age using the Infant Neurological International Battery INFANIBa neuromotor exam that tests posture, tone, reflexes, and motor skills, and using a visual habituation paradigm of a neutral female face.

Apomorphine causes considerable somnolence, and concomitant administration of apomorphine and CNS depressants like phenothiazines could result in additive CNS effects.

Fluphenazine decanoate or enanthate injections are administered via IM or subcutaneous injection only, do not administer intravenously. The flupuenazine of pharmacodynamic interactions varies based upon the individual properties of the co-administered antipsychotic agent.