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Como antiarrítmico: • Dosis inicial de carga: 1,25 mg/kg i.v en infusión intermitente, cada 5 min. hasta un total de 15mg/kg. • Mantenimiento. calculo de dosis factor goteo regla de tres. CONECTAR A EQUIPO MACRO IV DIRECTA FENITOINA (EPAMIN) ANTICONVULSIVANTE. DIFENILHIDANTOINA (Fenitoina) Mecanismo de Acción: . en el hígado y el 35 % de una dosis oral aparece en la orina, vida media 4 h.

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Cerebellum as a difenihlidantoina for toxic substances. Short periods of clampage 30 minutes and phenytoin low teratogenic doses at the same pregnancy phase induce mainly distal digital hypoplasia. Histological aspects of the epithelium of tongue’s posterior region of control group a and phenytoin treated group b. Neme 1 Estimated H-index: It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you.


Home International Fenitoina Print Share. Med J Aust1: Several mechanisms have been described, with the attempt to explain the changes observed here and also those reported in literature. Phenytoin – induced cleft palate: Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

The posterior dorsal region of the tongue showed to be less thick, comparing to the anterior region, however, with cell morphological characteristics very similar to the anterior region and, also showed the absence of granular and horny layers Fig.

Histopathological and morphometric changes at all lingual regions were observed. Longer periods of clampage minutes and higher phenytoin doses induce more serious malformations, as example: Decreased epithelium thickness and a greater number of cells in the treated group can be observed.


To view content sources and attributions, please refer to our editorial policy. Harald Masur 8 Estimated H-index: Available for Android and iOS devices.

Nevertheless his neurological examination still difenilhidanotina trunkal and lower limbs ataxia. Subscribe to receive email notifications whenever new articles are published. The decreased body weight of the treated fetus observed in this work reflected in the macroscopic morphological results with decreased values. After one year of follow up his neurological picture did not change, while he was seizures free.

Phenytoin-Related cerebellar degeneration without seizures. Prenatal exposure to phenytoin, facial development and, a possible role for vitamin K. The tongue mucosa of the fetuses, of treated mothers, showed changes in the three analyzed regions. By clicking Subscribe, I agree to the Drugs.

Arch Neurol Neurological sequelae following Dilantin overdose in a patient and in experimental animals. Webster; ; phenytoin: Cerebellar atrophy and persistent cerebellar ataxia after acute intoxication of phenytoin.

Cerebellar degeneration following long-term phenytoin teraphy. Kaeko Kitamura 1 Estimated H-index: In the anterior dorsal region of the tongue, the epithelium showed to be less thick, with no papilla; the cells from the prickle-cell and basal layer showed to be more rounded and morphologically very alike, and their nuclei showed loose chromatin, evident nucleolus, and two-nucleolus nuclei were often observed.

The heads were separated from the bodies, and then sectioned longitudinally. Phenytoin diphenylhydantoin, dilantin has been the chosen anti-convulsive for the treatment of sudden disorders since the late ‘s.

We comply with the HONcode standard for trustworthy health information – verify here. In order to support the hypoxia hypothesis, the malformations induced by the phenytoin are almost all identical to those, which can be observed after uterine vessels clampage.

Consult with your healthcare professional before taking any medication. Literature review and case presentation. This means it is still under development and may contain inaccuracies. Resaltar la importancia y posibilidad de efectuar un diagnostico precoz.


Cerebellar degeneration with clinical manifestation in chronic epileptic patients.

The average body weight of all treated animals was 4. Decreased epithelium thickness and papilla absence in the treated group can be observed. Karyometric parameters average values of the epithelium basal layer cells nucleus from anterior dorsal, posterior dorsal and ventral regions of the tongue of control C and treated T fetuses. Behavioral outcome after prenatal exposure to phenytoin in rats. Effect of prenatal phenytoin administration on postnatal development of the rat: Saunders,Vol 4, No 3, p.

Diphenylhydantoin teratogenicity in rats. The karyometric parameters for the lingual mucosa were: Cerebellar degeneration with epilepsy. Phenytoin may also be expelled by lactation Mirkin. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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Afterwards, the heads were dehydrated, diaphanized, included in paraffin, which was then sectioned in slices 6 micrometers thickthen colored in hematoxylin and eosin.

Posteriormente a la suspension de la DFH y la exeresis del quiste temporal mejoro su cuadro convulsivo, aunque quedo con ataxia dodis miembros inferiores y asinergia de tronco, cuadro con el que fue dado de alta.

Casilla D Temuco – Difnilhidantoina Tel.: One should remember that phenytoin acts in the fetus of rats and mice, decreasing DNA synthesis, as well as protein synthesis Netzloff et al.