74178 DATASHEET PDF

January 7, 2020   |   by admin

Part, Category. Description, 4-bit Shift Register. Company, ETC. Datasheet, Download datasheet. Quote. Find where to buy. Quote. # Store at. °C. 5-Formylcytosine (5-fC) (D5D4K) Rabbit mAb . as recommended in the antibody product datasheet) in 10 ml primary antibody. Datasheet PDF Download – 4-Bit Shift Register, data sheet.

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Like most websites, we make use of cookies to track your preferences. Is your country not in this list? Have trouble resetting your password? Application References Have you published research involving the use of our products? The upper panel shows the antibody only binding to the DNA fragment containing 5-fC, while the lower panel shows the membrane stained with methylene blue.

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You will receive an e-mail containing a link to start the recovery procedure within minutes. Have you published research involving the use of our products? The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals. Lower amounts of 5-hmC have been reported in various cancers including myeloid leukemia and melanoma 13, The global level of 5-hmC increases during brain development, and 5-hmC is enriched at promoter regions and poised enhancers.

We are committed to providing you with a productive and privacy-friendly website. Since then this modification has been discovered in many tissues, with the highest levels found in the brain 9.

(PDF) 74178 Datasheet download

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Our website shows product prices without login! As shown in the graph, the antibody only binds to the oligo containing 5-fC. Find your product 7417. Background Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2. We wish you a successful ! By proceeding on this website, you agree to the placement of these cookies.

The modified base itself is stable in vivo and interacts datasbeet various readers including MeCP2 11, If so we’d love to hear about it.

(Datasheet) pdf – 4-Bit Shift Register (1-page)

TET protein-mediated cytosine hydroxymethylation was initially demonstrated in mouse brain and embryonic stem cells 5, 8. Contact us and we will help you. Login Create new account. Many cells and tissues contain very low endogenous levels of 5-fC that may dataeheet below the detection limits of this antibody. Please refer to this dayasheet. The antibody was titrated against a single-stranded DNA oligo containing either unmodified cytosine or differentially modified cytosine 5-mC, 5-hmC, 5-caC, 5-fC.

The supporting documents available for this product can be downloaded below. Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2.

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Additionally, TET proteins can further oxidize 5-hmC to form 5-formylcytosine 5-fC and 5-carboxylcytosine 5-caCboth of which are excised by thymine-DNA datsheet TDGeffectively linking cytosine oxidation to the base excision repair pathway and supporting active cytosine demethylation 6,7. This product is intended for research purposes only. Datasheet Datasheet CST The current items in your cart are: Furthermore, there is an inverse correlation between levels of 5-hmC and histone H3K9 and H3K27 trimethylation, suggesting 7418 role for 5-hmC in gene activation The same sequence of a base pair DNA dataeheet was generated by PCR using exclusively unmodified cytosine, 5-methylcytosine 5-mC5-hydroxymethylcytosine 5-hmC5-carboxylcytosine 5-caCor 5-formylcytosine 5-fC.

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Please let us know! Please change your password to something memorable and secure upon logging in. Your credentials are incorrect or you are trying to login with a non-existing webshop account. While 5-fC and 5-caC appear to be short-lived intermediate species, there is mounting evidence showing that 5-hmC is a distinct epigenetic mark with various unique datashete 10, Product has been added to your cart.

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